The Finlayson Lake district in southeastern Yukon is a remnant of a Late Paleozoic arc–back-arc system that consists of metamorphosed volcanic, plutonic, and sedimentary rocks of the Yukon-Tanana and Slide Mountain terranes. These rocks host more than 40 Mt of polymetallic resources in numerous occurrences and styles of volcanogenic massive sulphide (VMS) mineralization. Geochemical data from these rocks support previous interpretations that volcanism and plutonism occurred in arc–marginal arc (e.g., Fire Lake formation) and continental back-arc basin environments (e.g., Kudz Ze Kayah formation, Wind Lake formation, and Wolverine Lake group) where felsic magmatism formed from varying mixtures of crust and mantle-derived material. The rocks have elevated high field strength element (HFSE) and rare earth element (REE) concentrations in VMS-proximal stratigraphy relative to VMS-barren assemblages, suggesting that the petrogenetic conditions that generated felsic rocks likely played a role in the localization of VMS mineralization. Future work aims to constrain magmatic processes and outline prospectivity criteria for delineating productive VMS assemblages within the district, and in similar geodynamic settings globally.