A reconnaissance inventory of permafrost-related landslides in the Pelly River watershed was conducted in 2006, largely in response to local community concerns regarding the potential impacts of climate change on slope stability and possible effects on water quality. Using aerial photograph analysis, satellite imagery, and visual inspection from a fixed-wing aircraft, over 100 permafrostrelated slides were located near the Pelly and MacMillan rivers and various tributaries. Basic geomorphic characteristics were determined for many of the failures based on analysis of remote sensing data, and reviews of existing literature and surficial geology maps. Most of the landslides identified were small active-layer detachments and retrogressive thaw failures. Several large failures also illustrate important characteristics associated with permafrost-related landslides, including their source-area setting, triggers, high mobility, the longevity of their activity and their ability to impact very large areas. The nature and distribution of the identified failures highlights a number of implications for land-use in central Yukon and emphasizes the need for enhanced methods of permafrost detection and regional mapping in the Territory.