Southern Wolf Lake (105B), southeastern Teslin (105C) and northern Jennings River (104O) map areas contain a wide variety of styles of mineralization, including carbonate replacement deposits, skarns, greisens and veins, as well as several apparently stratiform occurrences that have been interpreted to be syngenetic in origin. Lead isotopic compositions of galena and other sulphide minerals from many of these occurrences help to constrain the nature and approximate age of individual occurrences. Preliminary results of this study indicate that most mineralization in the area, including that at Dan, Logan, Logtung, Arsenault, Fiddler and Hart occurrences, is epigenetic and of Mesozoic to Early Tertiary age. Galena analyses from the Cabin Lake and Mor occurrences in southwestern Wolf Lake and southeastern Teslin map areas, respectively, yield relatively non-radiogenic compositions that are consistent with a syngenetic (VMS) origin and broadly Devono-Mississippian age.